MSA-Regularized Protein Sequence Transformer toward Predicting Genome-Wide Chemical-Protein Interactions: Application to GPCRome Deorphanization

Small molecules play a vital position in modulating organic techniques. Knowledge of chemical-protein interactions helps handle elementary and sensible questions in biology and medication. However, with the fast emergence of newly sequenced genes, the endogenous or surrogate ligands of an unlimited variety of proteins stay unknown. Homology modeling and machine…

Life-stage dependent supergene haplotype frequencies and metapopulation neutral genetic patterns of Atlantic cod, Gadus morhua, from Canada’s Northern cod stock region and adjacent areas

Among extremely migratory fish species, nursery areas occupied by juveniles usually differ from grownup habitats. To higher perceive the spatial dynamics of Canada’s Northern cod stock, juveniles caught off the east coast of Newfoundland and Labrador had been in comparison with adults from the identical region in addition to people…